Quantum: Automated Cell Culture (2024)

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Quantum: Automated Cell Culture (3)

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Quantum Flex Cell Expansion System

Videos Compare Materials Cell Therapy Technologies

Quantum: Automated Cell Culture (6)

Are you ready for the next generation of cell expansion? Automate the right way, right from the start with the Quantum Flex Cell Expansion System. Gain the flexibility, scalability and connectivity to grow with your therapy, from process development to commercial manufacturing.

Learn More About Quantum Flex

Solution overview

Quantum: Automated Cell Culture (7)
An automated and functionally closed platform expands a variety of suspension and adherent cell types
Quantum: Automated Cell Culture (8)
Multiple sizes of hollow-fiber bioreactors enable scalable, perfusion-based cell culture
Quantum: Automated Cell Culture (9)
Robust software facilitates fleet and device management and GMP compliance

Quantum: Automated Cell Culture (10)

For cell cultured on the Quantum Flex platform, thriving means:

  • Ready access to fresh media, waste removal and gas exchange over micrometer distances
  • A robust environment for both suspension and adherent cell culture
  • Precisely controlled, low-shear expansion
  • Reduced usage of valuable reagents

Suspension Cell Expansion

  • T cells
  • T-regs
  • Tumor Infiltrating Lymphocytes (TILs)
  • CAR-T cells
  • CD34+ cells

Adherent Cell Expansion

  • Human pluripotent stem cells (ESCs, iPSCs)
  • Mesenchymal stem cells (MSCs)
  • Fibroblasts
  • Endothelial cells
  • Neural stem cells (NSCs)

Applications

  • Viral vector production using adherent and suspension HEK293 cells
  • Exosome production

Quantum: Automated Cell Culture (11)

Quantum: Automated Cell Culture (12) Performance varies by user and is dependent on customer processes and materials.

SEE HOW QUANTUM FLEX CAN WORK IN YOUR FACILITY — REQUEST A CONSULTATION.

What if cell culture could harness the power
of perfusion?


Video (1 minute): What if cell culture could harness the power of perfusion as it occurs in the human body? Learn about hollow-fiber perfusion on Quantum Flex.

Demonstration From the Lab: Quantum Flex Cell Expansion System


Video (12 minutes): Visit the lab for a demonstration of key Quantum Flex features and benefits: flexibility, scalability, automation – and it facilitates GMP compliance.

How It Works

Dual loops for microenvironment control

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Quantum: Automated Cell Culture (14)

For suspension culture, complete media and reagents are gently pumped into both ends of the IC loop; main feeding and gas exchange are achieved via higher flow rate through the EC loop.

For adherent culture, feeding is achieved through low flow rate through the IC loop, while gas exchange is achieved via higher flow rate through the EC loop.

Quantum: Automated Cell Culture (15)

Quantum: Automated Cell Culture (16)

Compare Cell Culture Flasks to Automated Cell Culture

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Flasks

Labor-intensive, manual process

Quantum: Automated Cell Culture (18)
Quantum Flex

Automated, customizable process

Possibility of variation between lab personnel and each culture

Reproducible process and a high degree of scalability

Large number of open steps through the process

Functionally closed system from cell loading through harvest

Temperature fluctuations as flasks are moved in and out of the incubator

Continuous control of temperature

Manual pipette process to feed cells and remove waste

Automated perfusion system and customizable control of cell feeding and waste removal

Cell harvest spans hours/days*

Cells harvested in as little as 20 minutes


*Dependent on the number and capacity of flasks

Quantum: Automated Cell Culture (19)

Quantum: Automated Cell Culture (21)


Installation Qualification and Operational Qualification Services

Leverage our expertise and hands-on device experience to supply audit-quality data for your records.
Terumo Blood and Cell Technologies now provides installation qualification and operational
qualification services for Quantum Flex.

Learn More

The Cell Processing Application (CPA) software works with the device and disposables to provide a holistic, connected solution for cell expansion

Quantum: Automated Cell Culture (22)

  • Protocol builder and management across devices
  • Report management and advanced reporting capabilities
  • Remote monitoring and alarming
  • Flexible deployment configurations
  • Fleet management
  • One to 100 devices connected, with up to 12 users at a time

Materials

Access the information you need to automate the cell expansion steps in your cell therapy process.
See Full List of Materials

Brochures

Quantum Flex Product Brochure Download Simplify with Quantum Flex Download Scale with Quantum Flex Download Suspension cells on Quantum Flex Download Quantum Flex Accessories Download

On-Demand Webinars

Next Generation of Cell Expansion Webinar

Watch Now

Elevate your T-Cell Manufacturing Webinar

Watch Now

Cost-Benefit Analysis of Expanding Bone-Marrow-Derived Mesenchymal Stem Cells (MSCs) Using Automated Cell Expansion Methods Versus Manual Methods Presented byAthena Russell, MT (AAB)Lead Medical Laboratory Scientist and Assistant Professor,Mayo Clinic (Jacksonville, FL, USA) Register COVID-19 Experts Discuss Exosomes and MSCs to Treat ARDS in COVID-19 Panel includes Benn Buller, PhD, and Michael Matthay, MD Register

Featured Articles

Peer-Reviewed Article: Comparison of Automated Perfusion- and Manual Diffusion-Based Human Regulatory T-Cell Expansion and Functionality Using a Soluble Activator Complex

Peer-Reviewed Article: Large-Scale Expansion and Characterization of CD3+ T Cells in the Quantum Cell Expansion System

Mendt M, et al. JCI Insight. 2018;3(8):e99263. Sheu J, et al. Mol Ther Methods Clin Dev. 2015;2:15020. Russell AL, et al. Transfusion. 2018;58(10):2374-2382. Schive SW, et al. CellR4. 2018;6(2):e2519. Haack-Sørensen M, et al. J Transl Med. 2016;14(1):319. Haack-Sørensen M, et al. Scand J Clin Lab Invest. 2018;78(4):293-300. Mennan C, et al. Stem Cell Res Ther. 2019;10(1):99. Mizukami A, et al. Biochem Eng J. 2018;135:36-48. Hanley PJ, et al. Cytotherapy. 2014;16(8):1048-1058. Nankervis B, et al. Curr Stem Cell Rep. 2018;4(1):46-51. Coeshott C, et al. J Transl Med. 2019;17:258. Roberts I, et al. Biotech Lett. 2012;34(12):2307-2315. Paccola Mesquita FC, et al. Stem Cells Int. 2019;2019:9704945. Data on file.

Availability is subject to regulatory clearance

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