[PDF] Association of hypothyroid disease in Doberman Pinscher dogs with a rare major histocompatibility complex DLA class II haplotype. | Semantic Scholar (2024)

A further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown are reported.

The disease shows a complex pattern of inheritance, but the observed DLA class II association with DH suggests a role for the immune system in the development of the disease.

A limited MHC diversity in North American NSDTRs is indicated and it is suggested that the MHC may play a role in the development of hypoadrenocorticism in the N SDTR, supporting the autoimmune origin of the disease.

Routine screening of Alaskan husky dogs, as part of the state outreach science programme, identified a new DLA-DQA1 allele, DQA 1*01801, in one animal, and data suggest that husky alleles share as much similarity to wolf alleles as to dog alleles.

Results show that Giant Schnauzers carrying the haplotype DRB1*01201DQA1*00101DQB1*0020 have an increased risk to develop CLT, with an odds ratio of 6.0667 and with a p value of 0.015401 which shows that the increased risk of developing CLT is statistically significant.

This study assessed the relationship between particular MHC (dog leukocyte antigen, DLA) class II haplotypes and the two autoimmune diseases most common in bearded collies and suggested this two-locus (DQ) model serves as a good indicator for susceptibility to multiple organ-specific autoimmune diseases in the canine population.

Evidence is obtained that dog leukocyte antigen (DLA) class II genotype function as either genetic risk factor that predisposes for CLT or as protective factor against the disease.

Given the reported role of NF-κB in many human autoimmune diseases, the results suggest CLT as an excellent genetic model for human thyroiditis.

It is suggested that an underlying DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition.

DLA-DQB1 allele and CTLA4 promoter haplotype were not found to be significantly associated with IMHA in co*cker spaniels, with other genetic and environmental factors involved in disease expression and progression.

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It is suggested that a conserved amino acid motif in the 3HVR present in some DRB1 alleles of both dogs and humans is associated with rheumatoid arthritis in both species.

It appears likely that the extent of polymorphism of the DLA genes will increase substantially as dogs from a wider geographic distribution are studied, which has major implications for the study of disease susceptibility and immune responsiveness in dogs.

Thyroid function, as assessed by total thyroxine estimation, was depressed in hospitalized dogs compared with the thyroid function in healthy dogs, irrespective of thyroglobulin-antibody status.

Neutering was determined to be the most significant gender-associated risk factor for development of hypothyroidism and those with severe concurrent disease or neurologic abnormalities were less likely to respond with complete resolution of clinical signs.

Histologically proved thyroiditis indistinguishable from human Hashimoto’s struma was found to occur in 12.5 % of 541 males and 10.9% of 440 females in a purebred beagle colony started in 1958, and the use of stud “I” more than doubled the prevalence.

All but 4 of the published DLA-DRB1 alleles were identified in these animals and interbreed variation in both allele distributions and allele frequencies were observed, which may be useful in the study of genetic variation between breeds.

A molecular-based sequence-specific oligonucleotide probing method to identify all published DQA1 alleles and has used these methods to type a large number of dogs, providing a powerful tool for generating data that will be essential for studies investigating the genetic relationships between different breeds.

Thyroglobulin autoantibody was positive in 43 per cent of hypothyroid dogs with unexpectedly normal serum c TSH concentrations and was particularly useful in the classification of these cases.

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